# OnCo record drug-resistance-dynamics (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/drug-resistance-dynamics/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "drug-resistance-dynamics" ;
  schema:name "Evolutionary dynamics of drug resistance"@en ;
  schema:description "Mathematics from population genetics shows that resistant cells almost always exist before treatment in large tumours, and that combining drugs with different resistance mutations from the start can succeed where the same drugs in sequence fail."@en ;
  schema:url <https://onco.cc/technologies/drug-resistance-dynamics/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://doi.org/10.7554/eLife.00747> ;
  onco:status "established" ;
  onco:tag "mathematical-model" ;
  onco:sections <https://onco.cc/fronts/ai-computation/>, <https://onco.cc/fronts/drug-discovery/> ;
  onco:technologies <https://onco.cc/technologies/clonal-evolution-tracking/>, <https://onco.cc/technologies/adaptive-therapy-dynamics/>, <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-bozic-elife/> .