# OnCo record drug-response-splits (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/drug-response-splits/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "drug-response-splits" ;
  schema:name "Drug-response data splits: leave-cell-line-out, leave-drug-out, leave-tissue-out"@en ;
  schema:alternateName "leave-cell-line-out"@en, "LCO split"@en, "leave-drug-out"@en, "LDO split"@en, "leave-tissue-out"@en, "LTO split"@en, "leave-pair-out"@en, "random pair split"@en, "cross-study validation"@en ;
  schema:description "How a drug-response dataset is split decides what a model's accuracy means: hold out cell lines to test personalised prediction, hold out drugs to test drug design, hold out tissues to test repurposing; holding out random pairs only tests imputation."@en ;
  schema:url <https://onco.cc/terms/drug-response-splits/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/s41467-026-72903-w> ;
  onco:tag "cansim-terms" ;
  onco:related <https://onco.cc/terms/cancer-ai-vocabulary/> ;
  onco:terms <https://onco.cc/terms/data-leakage/>, <https://onco.cc/terms/drug-response-baselines/>, <https://onco.cc/terms/drug-response-sensitivity/>, <https://onco.cc/terms/external-validation/> .