# OnCo record drug-tolerant-persisters (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/drug-tolerant-persisters/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "drug-tolerant-persisters" ;
  schema:name "Drug-tolerant persister cells"@en ;
  schema:description "Even when a drug wipes out 99% of a tumour, a few cells survive without any resistance mutation: they go quiet, stop dividing, and wait. These persisters are the seed of relapse. They are hard to kill precisely because they are not doing much, but they have their own weaknesses."@en ;
  schema:url <https://onco.cc/pathways/drug-tolerant-persisters/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Persister_cell> ;
  schema:citation <https://doi.org/10.1016/j.cell.2010.02.027>, <https://doi.org/10.1016/j.cell.2020.10.027> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:technologies <https://onco.cc/technologies/mrd-testing/>, <https://onco.cc/technologies/continuous-ctdna-monitoring/>, <https://onco.cc/technologies/epigenetic-drugs/>, <https://onco.cc/technologies/senescence-targeting/>, <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/ezh2/>, <https://onco.cc/targets/bcl2/>, <https://onco.cc/targets/kras/>, <https://onco.cc/targets/braf/> ;
  onco:drugs <https://onco.cc/drugs/osimertinib/>, <https://onco.cc/drugs/amivantamab/>, <https://onco.cc/drugs/lazertinib/>, <https://onco.cc/drugs/venetoclax/>, <https://onco.cc/drugs/signatera/> ;
  onco:pathways <https://onco.cc/pathways/ferroptosis-cell-death/>, <https://onco.cc/pathways/epigenetic-reprogramming/>, <https://onco.cc/pathways/autophagy/>, <https://onco.cc/pathways/senescence/>, <https://onco.cc/pathways/clonal-evolution/>, <https://onco.cc/pathways/cancer-stem-cells-plasticity/>, <https://onco.cc/pathways/resistance-routes-map/> ;
  onco:terms <https://onco.cc/terms/mrd/>, <https://onco.cc/terms/ctdna/>, <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/nonmutational-epigenetic-reprogramming/>, <https://onco.cc/terms/c797s/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-dormancy-mrd/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-sharma-cell/>, <https://onco.cc/key-papers/paper-shen-cell/> .