# OnCo record egfr-c797s (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/egfr-c797s/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "egfr-c797s" ;
  schema:name "EGFR C797S (and its phase with T790M)"@en ;
  schema:alternateName "C797S"@en, "EGFR C797S"@en, "C797S in cis"@en, "C797S in trans"@en, "Cys797Ser"@en ;
  schema:description "A change in the EGFR protein that removes the anchor point the newest lung cancer pills grip. Whether it can be worked around depends on whether it sits on the same copy of the gene as the earlier resistance change or on the other copy."@en ;
  schema:url <https://onco.cc/biomarkers/egfr-c797s/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nm.3854>, <https://doi.org/10.1001/jamaoncol.2018.2969>, <https://www.cbioportal.org/study/summary?id=luad_mskcc_2023_met_organotropism> ;
  onco:tag "biomarker", "resistance" ;
  onco:related <https://onco.cc/biomarkers/egfr-t790m/>, <https://onco.cc/biomarkers/egfr-exon-19-deletion/>, <https://onco.cc/biomarkers/egfr-l858r/> ;
  onco:cancers <https://onco.cc/cancers/nsclc/> ;
  onco:technologies <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/liquid-biopsy/> ;
  onco:targets <https://onco.cc/targets/egfr/> ;
  onco:pathways <https://onco.cc/pathways/resistance-routes-map/>, <https://onco.cc/pathways/rtk-activation/> ;
  onco:terms <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/egfr-mutation-subtypes/>, <https://onco.cc/terms/ctdna/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-thress-nat-med/>, <https://onco.cc/key-papers/paper-oxnard-osimertinib-resistance-mechanisms-jama-oncol-2018/> .