# OnCo record egfr-inhibitor-rash-prophylaxis (protocol). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/protocols/egfr-inhibitor-rash-prophylaxis/>
  a schema:MedicalGuideline ;
  onco:kind "protocol" ;
  schema:identifier "egfr-inhibitor-rash-prophylaxis" ;
  schema:name "EGFR inhibitor rash: pre-emptive skin care, antibiotics and dose changes"@en ;
  schema:alternateName "EGFR inhibitor rash prophylaxis"@en, "acneiform rash"@en, "papulopustular rash"@en, "pre-emptive doxycycline"@en, "pre-emptive skin treatment"@en, "cetuximab rash"@en, "panitumumab rash"@en, "amivantamab skin care"@en, "COCOON regimen"@en, "STEPP regimen"@en ;
  schema:description "Drugs that block EGFR, such as cetuximab, panitumumab, amivantamab and EGFR tablets for lung cancer, very often cause an acne-like rash. Starting skin care on day one makes a bad rash much less likely: doxycycline or minocycline for the first weeks, moisturiser, sunscreen, and sometimes a mild steroid cream. Tell your team early if it spreads or hurts: a pause or lower dose may help."@en ;
  schema:url <https://onco.cc/protocols/egfr-inhibitor-rash-prophylaxis/> ;
  schema:dateModified "2026-11-11"^^xsd:date ;
  onco:tag "protocol", "skin-toxicity", "egfr-inhibitor", "supportive-care" ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/egfr-mutant-nsclc/> ;
  onco:sections <https://onco.cc/fronts/supportive-care/> ;
  onco:drugs <https://onco.cc/drugs/cetuximab/>, <https://onco.cc/drugs/panitumumab/>, <https://onco.cc/drugs/amivantamab/>, <https://onco.cc/drugs/lazertinib/>, <https://onco.cc/drugs/erlotinib/>, <https://onco.cc/drugs/gefitinib/>, <https://onco.cc/drugs/afatinib/>, <https://onco.cc/drugs/osimertinib/>, <https://onco.cc/drugs/hydrocortisone/> ;
  onco:terms <https://onco.cc/terms/rash-skin-toxicity/>, <https://onco.cc/terms/chemotherapy-side-effects-colorectal/> .