# OnCo record eliana (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/eliana/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "eliana", "NCT02435849" ;
  schema:name "ELIANA"@en ;
  schema:description "ELIANA was the global trial behind the first CAR-T approval: a single infusion of tisagenlecleucel put four in five children and young adults with relapsed B-cell acute lymphoblastic leukaemia and no standard treatment remaining into remission, and most responders were still in remission without further therapy at the five-year update. Severe cytokine release syndrome affected almost half."@en ;
  schema:url <https://onco.cc/trials/eliana/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT02435849> ;
  onco:status "positive" ;
  onco:phase "2" ;
  schema:startDate "2015-04-08" ;
  onco:cancers <https://onco.cc/cancers/all-leukemia/>, <https://onco.cc/cancers/all-paediatric-relapsed/> ;
  onco:technologies <https://onco.cc/technologies/car-t/> ;
  onco:targets <https://onco.cc/targets/cd19/> ;
  onco:drugs <https://onco.cc/drugs/tisagenlecleucel/> ;
  onco:companies <https://onco.cc/companies/novartis/> ;
  onco:terms <https://onco.cc/terms/crs/> ;
  onco:people <https://onco.cc/people/stephan-grupp/>, <https://onco.cc/people/emily-whitehead/> .