# OnCo record enrich (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/enrich/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "enrich" ;
  schema:name "ENRICH"@en ;
  schema:alternateName "Ibrutinib and rituximab versus immunochemotherapy in mantle cell lymphoma"@en, "ENRICH trial"@en, "EudraCT 2015-000832-13"@en ;
  schema:description "A British and Nordic trial took chemotherapy out of first-line treatment for older people with mantle cell lymphoma and found the two-drug, chemotherapy-free combination worked better."@en ;
  schema:url <https://onco.cc/trials/enrich/> ;
  schema:dateModified "2026-10-01"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/S0140-6736(25)01432-1>, <https://www.clinicaltrialsregister.eu/ctr-search/search?query=2015-000832-13> ;
  onco:status "positive" ;
  onco:tag "lymphoma-evidence" ;
  onco:phase "2/3" ;
  schema:startDate "2016-02" ;
  onco:cancers <https://onco.cc/cancers/mantle-cell-lymphoma/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:sections <https://onco.cc/fronts/targeted-therapy/>, <https://onco.cc/fronts/chemotherapy/> ;
  onco:targets <https://onco.cc/targets/btk/>, <https://onco.cc/targets/cd20/>, <https://onco.cc/targets/ccnd1/> ;
  onco:drugs <https://onco.cc/drugs/ibrutinib/>, <https://onco.cc/drugs/rituximab/>, <https://onco.cc/drugs/bendamustine/>, <https://onco.cc/drugs/cyclophosphamide/>, <https://onco.cc/drugs/doxorubicin/>, <https://onco.cc/drugs/vincristine/>, <https://onco.cc/drugs/prednisone/> ;
  onco:institutions <https://onco.cc/institutions/cruk/> ;
  onco:pathways <https://onco.cc/pathways/bcr-signalling/> ;
  onco:terms <https://onco.cc/terms/r-chop/>, <https://onco.cc/terms/maintenance-therapy/> ;
  onco:trials <https://onco.cc/trials/shine/>, <https://onco.cc/trials/triangle/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-toxicity-qol/>, <https://onco.cc/bottlenecks/b-aging-comorbidity/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-enrich-ibrutinib-rituximab-mantle-cell-lancet-2025/> .