# OnCo record enthuse-m1-zibotentan (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/enthuse-m1-zibotentan/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "enthuse-m1-zibotentan", "NCT00554229" ;
  schema:name "ENTHUSE M1"@en ;
  schema:alternateName "ENTHUSE M1"@en, "ENTHUSE 14"@en, "ZD4054 in bone-metastatic CRPC"@en ;
  schema:description "A drug blocking the endothelin signal that prostate cancer uses in bone did not extend life, and it caused swelling, headaches and heart failure."@en ;
  schema:url <https://onco.cc/trials/enthuse-m1-zibotentan/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT00554229>, <https://doi.org/10.1002/cncr.27674> ;
  onco:status "negative" ;
  onco:phase "3" ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mcrpc/> ;
  onco:targets <https://onco.cc/targets/ednra/> ;
  onco:drugs <https://onco.cc/drugs/zibotentan/> ;
  onco:companies <https://onco.cc/companies/astrazeneca/> ;
  onco:terms <https://onco.cc/terms/bone-metastases/>, <https://onco.cc/terms/castration-resistance/> ;
  onco:trials <https://onco.cc/trials/swog-s0421-atrasentan/> .