# OnCo record epacadostat (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/epacadostat/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "epacadostat" ;
  schema:name "Epacadostat"@en ;
  schema:description "An enzyme blocker meant to stop tumours starving T cells of tryptophan. Its 2018 phase 3 failure ended an entire class overnight."@en ;
  schema:url <https://onco.cc/drugs/epacadostat/> ;
  schema:dateModified "2026-09-06"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Epacadostat> ;
  owl:sameAs <http://www.wikidata.org/entity/Q27077199> ;
  schema:citation <https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(19)30274-8/fulltext> ;
  onco:status "negative" ;
  onco:tag "failure", "lesson:phase-2-mirage" ;
  onco:modality "Small molecule (IDO1 inhibitor)" ;
  onco:cancers <https://onco.cc/cancers/melanoma/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:targets <https://onco.cc/targets/ido1/> ;
  onco:drugs <https://onco.cc/drugs/pembrolizumab/> ;
  onco:companies <https://onco.cc/companies/merck/> ;
  onco:trials <https://onco.cc/trials/nct03260894/>, <https://onco.cc/trials/nct03358472/>, <https://onco.cc/trials/nct03348904/> .