# OnCo record epigenetic-reprogramming (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/epigenetic-reprogramming/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "epigenetic-reprogramming" ;
  schema:name "Epigenetic reprogramming"@en ;
  schema:description "Cancer changes not just its genes but how they are read: chemical tags on DNA and histones silence guardians and awaken growth programmes. Unlike mutations, these changes are reversible, which is the hope behind epigenetic drugs."@en ;
  schema:url <https://onco.cc/pathways/epigenetic-reprogramming/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Cancer_epigenetics> ;
  owl:sameAs <http://www.wikidata.org/entity/Q5031434> ;
  schema:citation <https://doi.org/10.1158/2159-8290.CD-21-1059>, <https://doi.org/10.1101/cshperspect.a019505> ;
  onco:tag "mechanism" ;
  onco:related <https://onco.cc/terms/epigenetic-progenitor-theory/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:technologies <https://onco.cc/technologies/epigenetic-drugs/>, <https://onco.cc/technologies/methylation-profiling/>, <https://onco.cc/technologies/mced/> ;
  onco:targets <https://onco.cc/targets/idh/>, <https://onco.cc/targets/ezh2/>, <https://onco.cc/targets/menin/>, <https://onco.cc/targets/kmt2a/>, <https://onco.cc/targets/npm1/>, <https://onco.cc/targets/tet2/>, <https://onco.cc/targets/brd4/> ;
  onco:drugs <https://onco.cc/drugs/azacitidine/>, <https://onco.cc/drugs/revumenib/>, <https://onco.cc/drugs/ziftomenib/>, <https://onco.cc/drugs/vorasidenib/> ;
  onco:institutions <https://onco.cc/institutions/johns-hopkins/>, <https://onco.cc/institutions/dkfz/>, <https://onco.cc/institutions/dana-farber/>, <https://onco.cc/institutions/mskcc/> ;
  onco:pathways <https://onco.cc/pathways/swi-snf-chromatin/>, <https://onco.cc/pathways/cancer-stem-cells-plasticity/>, <https://onco.cc/pathways/er-signaling/> ;
  onco:terms <https://onco.cc/terms/nonmutational-epigenetic-reprogramming/>, <https://onco.cc/terms/mgmt/>, <https://onco.cc/terms/h3k27m/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-baylin-cold-spring-harb-perspect-biol/> .