# OnCo record epigenetics-roadmap (roadmap). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/roadmaps/epigenetics-roadmap/>
  a schema:CreativeWork ;
  onco:kind "roadmap" ;
  schema:identifier "epigenetics-roadmap" ;
  schema:name "Epigenetic therapy roadmap: loosening silenced genes → mutation-specific enzymes → editing the epigenome"@en ;
  schema:description "Epigenetic drugs change how genes are read rather than the genes themselves. They started as gentle chemotherapy for blood cancers and are becoming precise drugs against the enzymes and scaffolds that particular cancers depend on."@en ;
  schema:url <https://onco.cc/roadmaps/epigenetics-roadmap/> ;
  schema:dateModified "2026-09-10"^^xsd:date ;
  schema:citation <https://doi.org/10.1101/cshperspect.a019505>, <https://doi.org/10.1038/s41586-023-05812-3> ;
  onco:related <https://onco.cc/ideas/idea-bio1-fusion-tf-degraders/>, <https://onco.cc/companies/k36-therapeutics/>, <https://onco.cc/companies/arpeggio-bio/>, <https://onco.cc/companies/morphosys/>, <https://onco.cc/companies/chipscreen/>, <https://onco.cc/key-papers/paper-indigo-nejm-2023/>, <https://onco.cc/key-papers/paper-viale-a-venetoclax-azacitidine-nejm-2020/>, <https://onco.cc/key-papers/paper-augment-101-revumenib-menin-nature-2023/>, <https://onco.cc/key-papers/paper-hallmarks-new-dimensions-cancer-discov-2022/>, <https://onco.cc/roadmaps/targeted-therapy-roadmap/> ;
  onco:sections <https://onco.cc/fronts/epigenetics/> ;
  onco:technologies <https://onco.cc/technologies/epigenetic-drugs/>, <https://onco.cc/technologies/epigenetic-editing/>, <https://onco.cc/technologies/protac-degrader/>, <https://onco.cc/technologies/methylation-profiling/> ;
  onco:targets <https://onco.cc/targets/menin/>, <https://onco.cc/targets/ezh2/>, <https://onco.cc/targets/idh/>, <https://onco.cc/targets/hdac/>, <https://onco.cc/targets/prmt5-mtap/> ;
  onco:drugs <https://onco.cc/drugs/azacitidine/>, <https://onco.cc/drugs/decitabine/>, <https://onco.cc/drugs/decitabine-cedazuridine/>, <https://onco.cc/drugs/vorinostat/>, <https://onco.cc/drugs/romidepsin/>, <https://onco.cc/drugs/belinostat/>, <https://onco.cc/drugs/panobinostat/>, <https://onco.cc/drugs/tucidinostat/>, <https://onco.cc/drugs/ivosidenib/>, <https://onco.cc/drugs/enasidenib/>, <https://onco.cc/drugs/olutasidenib/>, <https://onco.cc/drugs/vorasidenib/>, <https://onco.cc/drugs/tazemetostat/>, <https://onco.cc/drugs/revumenib/>, <https://onco.cc/drugs/ziftomenib/>, <https://onco.cc/drugs/venetoclax/>, <https://onco.cc/drugs/mevrometostat/>, <https://onco.cc/drugs/golcadomide/>, <https://onco.cc/drugs/eprenetapopt/> ;
  onco:pathways <https://onco.cc/pathways/epigenetic-reprogramming/>, <https://onco.cc/pathways/transcription-addiction/>, <https://onco.cc/pathways/menin-kmt2a/>, <https://onco.cc/pathways/idh-2hg/>, <https://onco.cc/pathways/swi-snf-chromatin/>, <https://onco.cc/pathways/myc/> ;
  onco:terms <https://onco.cc/terms/hma/>, <https://onco.cc/terms/nonmutational-epigenetic-reprogramming/> ;
  onco:trials <https://onco.cc/trials/viale-a/>, <https://onco.cc/trials/agile/>, <https://onco.cc/trials/augment-101/>, <https://onco.cc/trials/komet-001/>, <https://onco.cc/trials/mevpro-1/>, <https://onco.cc/trials/claridhy/>, <https://onco.cc/trials/golseek-1/> ;
  onco:people <https://onco.cc/people/stephen-baylin/>, <https://onco.cc/people/pierre-fenaux/>, <https://onco.cc/people/courtney-dinardo/>, <https://onco.cc/people/eytan-stein/>, <https://onco.cc/people/ghayas-issa/>, <https://onco.cc/people/ingo-mellinghoff/>, <https://onco.cc/people/christopher-vakoc/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-undruggable-targets/>, <https://onco.cc/bottlenecks/b-resistance/>, <https://onco.cc/bottlenecks/b-tumor-heterogeneity/>, <https://onco.cc/bottlenecks/b-biomarker-validation/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-baylin-cold-spring-harb-perspect-biol/> .