# OnCo record er-signaling (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/er-signaling/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "er-signaling" ;
  schema:name "Oestrogen receptor signalling"@en ;
  schema:description "In hormone-positive breast cancer, oestrogen binds its receptor, which switches on genes that make the cell divide. Every endocrine therapy cuts this chain somewhere."@en ;
  schema:url <https://onco.cc/pathways/er-signaling/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Estrogen_receptor> ;
  owl:sameAs <http://www.wikidata.org/entity/Q416496> ;
  schema:citation <https://en.wikipedia.org/wiki/Estrogen_receptor> ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/> ;
  onco:technologies <https://onco.cc/technologies/endocrine-therapy/>, <https://onco.cc/technologies/protac-degrader/>, <https://onco.cc/technologies/cdk46-inhibitor/> ;
  onco:targets <https://onco.cc/targets/estrogen-receptor/>, <https://onco.cc/targets/cdk4-6/>, <https://onco.cc/targets/pik3ca/> ;
  onco:drugs <https://onco.cc/drugs/vepdegestrant/>, <https://onco.cc/drugs/elacestrant/>, <https://onco.cc/drugs/palbociclib/>, <https://onco.cc/drugs/ribociclib/>, <https://onco.cc/drugs/abemaciclib/> .