# OnCo record era-223 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/era-223/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "era-223", "NCT02043678" ;
  schema:name "ERA 223"@en ;
  schema:alternateName "ERA 223"@en, "ERA223"@en ;
  schema:description "Combining a bone-seeking radioactive drug with abiraterone did not help, and it nearly tripled the rate of broken bones. The trial was unblinded early and the combination is now contraindicated."@en ;
  schema:url <https://onco.cc/trials/era-223/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT02043678>, <https://doi.org/10.1016/S1470-2045(18)30860-X> ;
  onco:status "negative" ;
  onco:phase "3" ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mcrpc/> ;
  onco:technologies <https://onco.cc/technologies/targeted-alpha-therapy/>, <https://onco.cc/technologies/androgen-deprivation/> ;
  onco:drugs <https://onco.cc/drugs/radium-223/>, <https://onco.cc/drugs/abiraterone/>, <https://onco.cc/drugs/prednisone/> ;
  onco:companies <https://onco.cc/companies/bayer/> ;
  onco:terms <https://onco.cc/terms/bone-metastases/>, <https://onco.cc/terms/castration-resistance/> ;
  onco:trials <https://onco.cc/trials/peace-3/>, <https://onco.cc/trials/alsympca/> .