# OnCo record erlotinib (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/erlotinib/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "erlotinib" ;
  schema:name "Erlotinib"@en ;
  schema:description "Erlotinib was one of the first EGFR pills for lung cancer; it was approved before anyone knew EGFR mutations predicted who would respond, then redefined by them."@en ;
  schema:url <https://onco.cc/drugs/erlotinib/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Erlotinib> ;
  owl:sameAs <http://www.wikidata.org/entity/Q418369> ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=erlotinib>, <https://www.ema.europa.eu/en/medicines/human/EPAR/tarceva>, <https://doi.org/10.1200/JCO.2017.72.6463>, <https://doi.org/10.1097/COC.0000000000000633> ;
  onco:status "approved" ;
  onco:tag "gap-fill", "generic" ;
  onco:modality "Small-molecule EGFR TKI (first generation, reversible)" ;
  schema:alternateName "Tarceva" ;
  onco:approval "US 2004: Locally advanced/metastatic NSCLC after chemotherapy", "US 2005: Pancreatic cancer with gemcitabine", "US 2013: First-line NSCLC with EGFR exon 19 del or L858R", "EU 2007: Metastatic pancreatic cancer with gemcitabine (Tarceva product information: factors associated with prolonged survival should be taken into account when prescribing; 100 mg daily); marketing authorisation for the product 19 September 2005" ;
  onco:cancers <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/egfr-mutant-nsclc/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/egfr/> ;
  onco:companies <https://onco.cc/companies/roche-genentech/>, <https://onco.cc/companies/astellas/> ;
  onco:terms <https://onco.cc/terms/egfr-exon19-l858r/>, <https://onco.cc/terms/histology/> ;
  onco:trials <https://onco.cc/trials/nct02152631/>, <https://onco.cc/trials/nct02411448/>, <https://onco.cc/trials/nct05442060/>, <https://onco.cc/trials/conko-005/>, <https://onco.cc/trials/lap07/> .