# OnCo record esr1-mutation (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/esr1-mutation/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "esr1-mutation" ;
  schema:name "ESR1 mutation"@en ;
  schema:alternateName "ESR1"@en, "ESR1 mutations"@en, "ESR1-mutant"@en, "ESR1-mutated"@en, "ESR1m"@en, "ESR1 mutation on ctDNA"@en, "ESR1 ctDNA testing"@en, "oestrogen receptor gene mutation"@en, "estrogen receptor gene mutation"@en, "Y537S"@en, "D538G"@en, "ESR1 ligand-binding domain mutation"@en ;
  schema:description "A change in the oestrogen receptor gene that lets the cancer grow without oestrogen, so aromatase inhibitors stop working. Found in the blood in about a third of patients after hormone therapy."@en ;
  schema:url <https://onco.cc/terms/esr1-mutation/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Estrogen_receptor_alpha> ;
  owl:sameAs <http://www.wikidata.org/entity/Q14902310> ;
  schema:citation <https://en.wikipedia.org/wiki/Estrogen_receptor_alpha> ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/> ;
  onco:technologies <https://onco.cc/technologies/liquid-biopsy/> ;
  onco:targets <https://onco.cc/targets/estrogen-receptor/> ;
  onco:drugs <https://onco.cc/drugs/elacestrant/>, <https://onco.cc/drugs/imlunestrant/>, <https://onco.cc/drugs/vepdegestrant/>, <https://onco.cc/drugs/camizestrant/> .