# OnCo record estrogen-receptor (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/estrogen-receptor/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "estrogen-receptor" ;
  schema:name "Estrogen receptor (ERα)"@en ;
  schema:description "The hormone switch that drives most breast cancers. Blocking or destroying it is the oldest and most effective targeted therapy."@en ;
  schema:url <https://onco.cc/targets/estrogen-receptor/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Estrogen_receptor_alpha>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3467>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000091831>, <https://www.uniprot.org/uniprotkb/P03372/entry>, <https://www.ncbi.nlm.nih.gov/gene/2099> ;
  owl:sameAs <http://www.wikidata.org/entity/Q14902310> ;
  schema:citation <https://en.wikipedia.org/wiki/Estrogen_receptor_alpha> ;
  onco:tag "hormonal" ;
  schema:alternateName "ESR1" ;
  onco:targetClass "nuclear-receptor" ;
  onco:firstDescribed "1986"^^xsd:gYear ;
  onco:related <https://onco.cc/biomarkers/er-status/>, <https://onco.cc/biomarkers/esr1-mutation-ctdna/> ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/endometrial/> ;
  onco:drugs <https://onco.cc/drugs/fluoroestradiol-f18/>, <https://onco.cc/drugs/guardant360-cdx/>, <https://onco.cc/drugs/toremifene/>, <https://onco.cc/drugs/raloxifene/>, <https://onco.cc/drugs/lns8801/> ;
  onco:pathways <https://onco.cc/pathways/er-signaling/>, <https://onco.cc/pathways/breast-cancer-signalling/>, <https://onco.cc/pathways/chemical-carcinogenesis-receptor-activation/>, <https://onco.cc/pathways/endometrial-cancer-signalling/> .