# OnCo record everolimus (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/everolimus/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "everolimus" ;
  schema:name "Everolimus"@en ;
  schema:description "An mTOR-blocking pill that doubled progression-free time with exemestane in 2012 and is now paired with the oral SERD giredestrant."@en ;
  schema:url <https://onco.cc/drugs/everolimus/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Everolimus> ;
  owl:sameAs <http://www.wikidata.org/entity/Q421052> ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Everolimus> ;
  onco:status "approved" ;
  onco:modality "Small-molecule mTOR inhibitor" ;
  schema:alternateName "Afinitor" ;
  onco:approval "US 2012: HR+/HER2- advanced breast cancer with exemestane after NSAI failure", "US 2011: Progressive pancreatic NETs", "US 2016: Progressive non-functional lung and GI NETs", "US 2009: Advanced RCC after sunitinib or sorafenib" ;
  onco:acceleratedApproval "US 2010-10-29: Patients with subependymal giant cell astrocytoma associated with tuberous sclerosis who require therapeutic intervention but are not candidates for curative surgical resection", "US 2012-04-26: Adults with renal angiomyolipma and tuberous sclerosis complex not requiring immediate surgery", "US 2012-08-29: Formulation: Pediatric and adult patients with tuberous sclerosis complex for treatment of subependymal giant cell astrocytoma that requires therapeutic intervention but cannot be curatively resected" ;
  onco:acceleratedApprovalConfirmed "US 2016-01-29: Patients with subependymal giant cell astrocytoma associated with tuberous sclerosis who require therapeutic intervention but are not candidates for curative surgical resection", "US 2016-01-29: Formulation: Pediatric and adult patients with tuberous sclerosis complex for treatment of subependymal giant cell astrocytoma that requires therapeutic intervention but cannot be curatively resected", "US 2016-02-18: Adults with renal angiomyolipma and tuberous sclerosis complex not requiring immediate surgery" ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/rcc/>, <https://onco.cc/cancers/neuroendocrine/>, <https://onco.cc/cancers/hr-positive-metastatic-post-cdk46/>, <https://onco.cc/cancers/chromophobe-rcc/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/pi3k-akt-mtor-inhibitors/> ;
  onco:targets <https://onco.cc/targets/pik3ca/>, <https://onco.cc/targets/akt/> ;
  onco:companies <https://onco.cc/companies/novartis/> ;
  onco:pathways <https://onco.cc/pathways/pi3k-akt-mtor/> ;
  onco:terms <https://onco.cc/terms/hyperglycaemia/> ;
  onco:trials <https://onco.cc/trials/evera/>, <https://onco.cc/trials/nct07165886/>, <https://onco.cc/trials/nct07002177/>, <https://onco.cc/trials/nct05563220/>, <https://onco.cc/trials/nct06428396/>, <https://onco.cc/trials/nct04919226/>, <https://onco.cc/trials/nct05573126/>, <https://onco.cc/trials/radiant-3-4/>, <https://onco.cc/trials/compete/>, <https://onco.cc/trials/litespark-005/>, <https://onco.cc/trials/clear/> .