# OnCo record exatecan (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/exatecan/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "exatecan" ;
  schema:name "Exatecan (and derivatives)"@en ;
  schema:alternateName "DX-8951"@en, "Ed-04"@en, "ZD06519"@en, "DX-8951; Ed-04 in iza-bren; ZD06519"@en ;
  schema:description "Exatecan is a camptothecin that blocks topoisomerase I; it was too toxic to use as a free chemotherapy, but attached to an antibody that toxicity becomes useful, and it is the parent of deruxtecan and most next-generation ADC payloads. The family shares resistance mechanisms, so switching between exatecan ADCs after progression often disappoints."@en ;
  schema:url <https://onco.cc/terms/exatecan/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Exatecan> ;
  owl:sameAs <http://www.wikidata.org/entity/Q5419343> ;
  schema:citation <https://en.wikipedia.org/wiki/Exatecan> ;
  onco:related <https://onco.cc/technologies/topoisomerase-inhibitors/>, <https://onco.cc/terms/adc-sequencing/> ;
  onco:technologies <https://onco.cc/technologies/adc/> ;
  onco:drugs <https://onco.cc/drugs/izalontamab-brengitecan/>, <https://onco.cc/drugs/tilatamig-samrotecan/>, <https://onco.cc/drugs/ak146d1/>, <https://onco.cc/drugs/puxitatug-samrotecan/> ;
  onco:terms <https://onco.cc/terms/payload/>, <https://onco.cc/terms/topoisomerase-i-payloads/> .