# OnCo record explorer (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/explorer/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "explorer", "NCT02561988" ;
  schema:name "EXPLORER"@en ;
  schema:alternateName "BLU-285-2101"@en ;
  schema:description "EXPLORER was the first human study of avapritinib, a pill designed to block the KIT D816V mutation that drives almost every case of advanced systemic mastocytosis; three quarters of evaluable patients responded and a third went into complete remission, and the drug was approved for the disease in 2021."@en ;
  schema:url <https://onco.cc/trials/explorer/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT02561988> ;
  onco:status "positive" ;
  onco:tag "soc-trials" ;
  onco:phase "1" ;
  onco:cancers <https://onco.cc/cancers/advanced-systemic-mastocytosis/>, <https://onco.cc/cancers/systemic-mastocytosis/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:drugs <https://onco.cc/drugs/avapritinib/> ;
  onco:companies <https://onco.cc/companies/blueprint-medicines/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-explorer-avapritinib-advanced-systemic-mastocytosis-nat-med-2021/> .