# OnCo record extreme (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/extreme/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "extreme", "NCT00122460" ;
  schema:name "EXTREME"@en ;
  schema:description "The regimen that defined first-line treatment for advanced head and neck cancer from 2008 until immunotherapy replaced it."@en ;
  schema:url <https://onco.cc/trials/extreme/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT00122460>, <https://www.nejm.org/doi/full/10.1056/NEJMoa0802656> ;
  onco:status "positive" ;
  onco:phase "3" ;
  schema:startDate "2004-12" ;
  onco:cancers <https://onco.cc/cancers/head-and-neck/>, <https://onco.cc/cancers/recurrent-metastatic-hnscc/> ;
  onco:technologies <https://onco.cc/technologies/monoclonal-antibody/>, <https://onco.cc/technologies/platinum/> ;
  onco:targets <https://onco.cc/targets/egfr/> ;
  onco:companies <https://onco.cc/companies/merck-kgaa/> ;
  onco:people <https://onco.cc/people/jan-vermorken/> .