# OnCo record extrinsic-apoptosis-death-receptors (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/extrinsic-apoptosis-death-receptors/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "extrinsic-apoptosis-death-receptors" ;
  schema:name "Extrinsic apoptosis (death receptors)"@en ;
  schema:description "Immune cells kill by touch: they present FAS ligand or TRAIL to a target cell, whose death receptors then trigger self-destruction from the outside in. Tumours cut this wire by deleting the receptors or over-producing decoys and blockers."@en ;
  schema:url <https://onco.cc/pathways/extrinsic-apoptosis-death-receptors/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Death_receptor> ;
  schema:citation <https://doi.org/10.1172/JCI80420> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:technologies <https://onco.cc/technologies/car-t/>, <https://onco.cc/technologies/t-cell-engager/>, <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/bh3-profiling/> ;
  onco:targets <https://onco.cc/targets/bcl2/>, <https://onco.cc/targets/cd3/>, <https://onco.cc/targets/pd1/> ;
  onco:drugs <https://onco.cc/drugs/venetoclax/> ;
  onco:pathways <https://onco.cc/pathways/apoptosis-bcl2/>, <https://onco.cc/pathways/pd1-checkpoint/>, <https://onco.cc/pathways/nk-cell-recognition/> ;
  onco:terms <https://onco.cc/terms/immunogenic-cell-death/>, <https://onco.cc/terms/adcc/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-ashkenazi-j-clin-invest/> .