# OnCo record ezh2 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/ezh2/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "ezh2" ;
  schema:name "EZH2"@en ;
  schema:alternateName "PRC2"@en, "EZH2" ;
  schema:description "EZH2 is an enzyme that silences genes. The first drug against it treated a rare sarcoma and some lymphomas until it was withdrawn in 2026 for causing second blood cancers."@en ;
  schema:url <https://onco.cc/targets/ezh2/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/EZH2>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3527>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000106462>, <https://www.uniprot.org/uniprotkb/Q15910/entry>, <https://www.ncbi.nlm.nih.gov/gene/2146> ;
  owl:sameAs <http://www.wikidata.org/entity/Q17917770> ;
  schema:citation <https://www.fda.gov/drugs/drug-alerts-and-statements/fda-alerts-health-care-providers-and-patients-about-increased-risk-new-blood-cancers-tazverik>, <https://doi.org/10.1038/ng.518> ;
  onco:tag "epigenetic" ;
  onco:targetClass "enzyme" ;
  onco:firstDescribed "1996"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/sarcoma/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/prostate-mcrpc/>, <https://onco.cc/cancers/prostate-nepc/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:drugs <https://onco.cc/drugs/xnw5004/> ;
  onco:companies <https://onco.cc/companies/oric-pharmaceuticals/>, <https://onco.cc/companies/treeline-biosciences/> ;
  onco:pathways <https://onco.cc/pathways/micrornas-in-cancer/>, <https://onco.cc/pathways/epigenetic-reprogramming/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-ku-rb1-trp53-lineage-plasticity-science-2017/> .