# OnCo record fak (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/fak/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "fak" ;
  schema:name "FAK (PTK2)"@en ;
  schema:alternateName "FAK"@en, "FAK1"@en, "FADK"@en, "focal adhesion kinase"@en, "protein tyrosine kinase 2"@en, "PTK2" ;
  schema:description "FAK is the kinase that tells a cell it is anchored to its surroundings, letting it survive, move and resist drugs. Defactinib, given with the RAF/MEK inhibitor avutometinib, removes that escape route in low-grade serous ovarian cancer; other FAK inhibitors are in trials in meningioma and solid tumours."@en ;
  schema:url <https://onco.cc/targets/fak/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9611>, <https://www.uniprot.org/uniprotkb/Q05397/entry>, <https://www.ncbi.nlm.nih.gov/gene/5747> ;
  onco:tag "wave5-target" ;
  onco:targetClass "kinase" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9611>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000169398>, <https://www.uniprot.org/uniprotkb/Q05397/entry>, <https://www.ncbi.nlm.nih.gov/gene/5747> ;
  onco:related <https://onco.cc/targets/kras/>, <https://onco.cc/targets/mek/> ;
  onco:cancers <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/low-grade-serous-ovarian-cancer/>, <https://onco.cc/cancers/meningioma/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/nsclc/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:drugs <https://onco.cc/drugs/avutometinib-defactinib/>, <https://onco.cc/drugs/gsk2256098/>, <https://onco.cc/drugs/in10018/> ;
  onco:pathways <https://onco.cc/pathways/invasion-ecm-degradation/>, <https://onco.cc/pathways/resistance-routes-map/> .