# OnCo record fasting-mimicking-diet (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/fasting-mimicking-diet/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "fasting-mimicking-diet" ;
  schema:name "Fasting and fasting-mimicking diets around chemotherapy"@en ;
  schema:description "Fasting-mimicking diets cut food intake for three days around each chemotherapy dose to lower glucose, insulin and IGF-1, which may shield normal cells and sensitise the tumour. The DIRECT trial in early breast cancer improved radiological response but fewer than 20% of patients kept to the diet, and it is unsafe in cachexia or without a dietitian."@en ;
  schema:url <https://onco.cc/technologies/fasting-mimicking-diet/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/s41467-020-16138-3> ;
  onco:status "phase-2" ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/colorectal/> ;
  onco:sections <https://onco.cc/fronts/nutrition-lifestyle/>, <https://onco.cc/fronts/chemotherapy/> ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/metabolic-therapy/> ;
  onco:pathways <https://onco.cc/pathways/pi3k-akt-mtor/> ;
  onco:terms <https://onco.cc/terms/energy-balance/>, <https://onco.cc/terms/warburg-effect-diet-claims/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-generic-repurposing/>, <https://onco.cc/bottlenecks/b-funding-allocation/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-de-groot-nat-commun/> .