# OnCo record field-cancerisation (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/field-cancerisation/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "field-cancerisation" ;
  schema:name "Field cancerisation"@en ;
  schema:description "Cancer often arises from a whole region of tissue that already carries mutations, not from one rogue cell. Sun-exposed skin, smokers' airways, and Barrett's oesophagus are patchworks of mutant clones competing long before a tumour appears."@en ;
  schema:url <https://onco.cc/pathways/field-cancerisation/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Field_cancerization> ;
  owl:sameAs <http://www.wikidata.org/entity/Q17119253> ;
  schema:citation <https://doi.org/10.1126/science.aau3879> ;
  onco:tag "mechanism" ;
  onco:related <https://onco.cc/terms/ageing-tissue-field-theory/>, <https://onco.cc/terms/topical-and-destructive-treatment-bcc/>, <https://onco.cc/terms/skin-cancer-after-organ-transplant/> ;
  onco:cancers <https://onco.cc/cancers/esophageal/>, <https://onco.cc/cancers/head-and-neck/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/cervical/>, <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/bowens-disease/>, <https://onco.cc/cancers/cutaneous-scc/>, <https://onco.cc/cancers/basal-cell-carcinoma/>, <https://onco.cc/cancers/skin-cancer/> ;
  onco:technologies <https://onco.cc/technologies/chemoprevention/>, <https://onco.cc/technologies/precancer-ablation/>, <https://onco.cc/technologies/endoscopic-resection/>, <https://onco.cc/technologies/hpv-vaccine/> ;
  onco:targets <https://onco.cc/targets/tp53/> ;
  onco:institutions <https://onco.cc/institutions/cruk/>, <https://onco.cc/institutions/francis-crick/>, <https://onco.cc/institutions/johns-hopkins/> ;
  onco:pathways <https://onco.cc/pathways/clonal-evolution/>, <https://onco.cc/pathways/epigenetic-reprogramming/> ;
  onco:terms <https://onco.cc/terms/barretts-esophagus/>, <https://onco.cc/terms/cin-hsil/>, <https://onco.cc/terms/actinic-keratosis/>, <https://onco.cc/terms/keratinocyte-cancer-counting/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-martincorena-science/> .