# OnCo record firefly-1 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/firefly-1/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "firefly-1", "NCT04775485" ;
  schema:name "FIREFLY-1"@en ;
  schema:description "FIREFLY-1 showed that a once-weekly pill, tovorafenib, shrinks most relapsed childhood low-grade gliomas driven by BRAF changes, including the common KIAA1549-BRAF fusion that older BRAF drugs could not treat safely. It led to the first approval of a drug for this disease."@en ;
  schema:url <https://onco.cc/trials/firefly-1/> ;
  schema:dateModified "2026-09-10"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT04775485>, <https://doi.org/10.1038/s41591-023-02668-y> ;
  onco:status "positive" ;
  onco:tag "nci-coverage", "paediatric", "cns" ;
  onco:phase "2" ;
  schema:startDate "2021-04-22" ;
  onco:cancers <https://onco.cc/cancers/paediatric-low-grade-glioma/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/braf/> ;
  onco:drugs <https://onco.cc/drugs/tovorafenib/> ;
  onco:companies <https://onco.cc/companies/day-one-biopharmaceuticals/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> ;
  onco:terms <https://onco.cc/terms/race-for-children-act/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-kilburn-nat-med/> .