# OnCo record first-in-human (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/first-in-human/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "first-in-human" ;
  schema:name "First-in-human (FIH) trial"@en ;
  schema:alternateName "first-in-human"@en, "first in human"@en, "FIH"@en, "first-in-human trial"@en, "first-in-human study"@en, "first-in-class"@en, "first in class"@en, "first-in-patient"@en, "phase 0"@en, "microdose"@en, "investigational new drug"@en, "IND-enabling"@en, "IND clearance"@en, "clinical entry"@en, "entered the clinic"@en, "clinical-stage"@en, "preclinical"@en, "pre-clinical"@en, "preclinical-stage"@en, "first-in-human studies"@en, "first-in-human trials"@en ;
  schema:description "The first time a new drug is given to people, after animal and laboratory testing and clearance of an Investigational New Drug application. In oncology these are phase 1 trials in patients with advanced cancer who have exhausted standard options, starting at a fraction of the dose predicted to be safe; modern designs run straight through to registrational cohorts."@en ;
  schema:url <https://onco.cc/terms/first-in-human/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Phase_I_clinical_trial> ;
  schema:citation <https://en.wikipedia.org/wiki/Phase_I_clinical_trial> ;
  onco:related <https://onco.cc/terms/dose-escalation-design/>, <https://onco.cc/terms/mtd/>, <https://onco.cc/terms/seamless-adaptive/>, <https://onco.cc/terms/window-of-opportunity-trial/>, <https://onco.cc/terms/trial-lifecycle/>, <https://onco.cc/terms/trial-phases/>, <https://onco.cc/terms/ethics-review/>, <https://onco.cc/terms/informed-consent/> ;
  onco:sections <https://onco.cc/fronts/drug-discovery/> .