# OnCo record fluorouracil-pharmacokinetic-dosing (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/fluorouracil-pharmacokinetic-dosing/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "fluorouracil-pharmacokinetic-dosing" ;
  schema:name "Fluorouracil dosing by measured blood level"@en ;
  schema:alternateName "5-FU therapeutic drug monitoring"@en, "5-FU AUC-guided dosing"@en, "pharmacokinetically guided fluorouracil dosing"@en, "PK-guided 5-FU dosing"@en, "fluorouracil TDM"@en ;
  schema:description "Fluorouracil is dosed by body size, yet the amount of drug in the blood varies widely between people given the same dose. Measuring the level during the infusion and adjusting the next dose raised the response rate from 18 to 34 per cent in one randomised trial and is recommended by an international pharmacology society, but it is not routine care and no survival gain has been established."@en ;
  schema:url <https://onco.cc/technologies/fluorouracil-pharmacokinetic-dosing/> ;
  schema:dateModified "2026-10-20"^^xsd:date ;
  schema:citation <https://doi.org/10.1200/JCO.2007.13.3934>, <https://doi.org/10.1002/cpt.1124>, <https://doi.org/10.1007/s00228-026-04174-9>, <https://doi.org/10.1093/jnci/djp328>, <https://doi.org/10.1634/theoncologist.2011-0357> ;
  onco:status "emerging" ;
  onco:tag "precision", "evidence:moderate" ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/head-and-neck/> ;
  onco:sections <https://onco.cc/fronts/chemotherapy/>, <https://onco.cc/fronts/supportive-care/> ;
  onco:technologies <https://onco.cc/technologies/body-surface-area-dosing/>, <https://onco.cc/technologies/dpyd-genotyping/>, <https://onco.cc/technologies/pkpd-modelling/>, <https://onco.cc/technologies/oral-targeted-therapy-drug-monitoring/> ;
  onco:drugs <https://onco.cc/drugs/fluorouracil/> ;
  onco:terms <https://onco.cc/terms/pharmacokinetics/>, <https://onco.cc/terms/therapeutic-index/>, <https://onco.cc/terms/dose-modification/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-dose-optimisation/> .