# OnCo record fluorouracil (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/fluorouracil/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "fluorouracil" ;
  schema:name "Fluorouracil (5-FU)"@en ;
  schema:description "The 1957 chemotherapy that remains the backbone of treatment for bowel, stomach, pancreatic, anal, head and neck and breast cancers, and as a cream for skin precancers."@en ;
  schema:url <https://onco.cc/drugs/fluorouracil/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Fluorouracil> ;
  owl:sameAs <http://www.wikidata.org/entity/Q238512> ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=fluorouracil%20injection>, <https://doi.org/10.1016/j.jid.2017.09.033>, <https://www.cancerresearchuk.org/about-cancer/skin-cancer/treatment/chemotherapy-cream>, <https://www.skinhealthinfo.org.uk/condition/basal-cell-carcinoma/> ;
  onco:status "approved" ;
  onco:tag "gap-fill", "generic", "who-essential" ;
  onco:modality "Fluoropyrimidine antimetabolite" ;
  schema:alternateName "Adrucil / Efudex" ;
  onco:approval "US 1962: Colorectal, breast, gastric and pancreatic adenocarcinoma", "US 1970: Topical: actinic keratosis and superficial basal cell carcinoma" ;
  onco:related <https://onco.cc/drugs/uridine-triacetate/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/gastric/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/anal/>, <https://onco.cc/cancers/esophageal/>, <https://onco.cc/cancers/head-and-neck/>, <https://onco.cc/cancers/basal-cell-carcinoma/>, <https://onco.cc/cancers/hepatoblastoma/>, <https://onco.cc/cancers/anal-hsil-precursor/>, <https://onco.cc/cancers/localised-anal-cancer/>, <https://onco.cc/cancers/localised-penile-cancer/>, <https://onco.cc/cancers/skin-cancer/> ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/> ;
  onco:companies <https://onco.cc/companies/mast-therapeutics/> ;
  onco:terms <https://onco.cc/terms/topical-and-destructive-treatment-bcc/> ;
  onco:trials <https://onco.cc/trials/int-0116/>, <https://onco.cc/trials/cao-aro-aio-94/>, <https://onco.cc/trials/dbcg-82bc/>, <https://onco.cc/trials/nct07775287/>, <https://onco.cc/trials/nct07676162/>, <https://onco.cc/trials/nct04430738/>, <https://onco.cc/trials/nct06107413/>, <https://onco.cc/trials/nct06792695/>, <https://onco.cc/trials/nct07805551/>, <https://onco.cc/trials/nct05009069/>, <https://onco.cc/trials/nct05846867/>, <https://onco.cc/trials/nct06820463/>, <https://onco.cc/trials/nct04421820/>, <https://onco.cc/trials/nct05379595/>, <https://onco.cc/trials/nct04675333/>, <https://onco.cc/trials/nct05489211/>, <https://onco.cc/trials/nct06428409/>, <https://onco.cc/trials/nct07554521/>, <https://onco.cc/trials/nct06469944/>, <https://onco.cc/trials/nct06901531/>, <https://onco.cc/trials/nct04241185/>, <https://onco.cc/trials/nct04379596/>, <https://onco.cc/trials/nct07069712/>, <https://onco.cc/trials/nct07256782/>, <https://onco.cc/trials/nct06780111/>, <https://onco.cc/trials/nct06922383/>, <https://onco.cc/trials/nct01954992/>, <https://onco.cc/trials/mal-pdt-imiquimod-fluorouracil-superficial-bcc/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-sauer-preoperative-chemoradiotherapy-rectal-nejm-2004/> .