# OnCo record focus4 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/focus4/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "focus4", "ISRCTN90061546" ;
  schema:name "FOCUS4"@en ;
  schema:alternateName "FOCUS4 trial"@en, "FOCUS4-N"@en, "FOCUS4-C"@en, "FOCUS4-D"@en, "MRC FOCUS4"@en ;
  schema:description "FOCUS4 was Britain's molecularly stratified platform in bowel cancer: after four months of chemotherapy, patients were sorted by their tumour's mutations and offered a matching maintenance drug or a break. Its two clear results were that a WEE1 inhibitor slowed cancers with both RAS and TP53 mutations, and that maintenance capecitabine delays progression but does not extend life."@en ;
  schema:url <https://onco.cc/trials/focus4/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://www.isrctn.com/ISRCTN90061546>, <https://doi.org/10.1200/JCO.21.01435>, <https://doi.org/10.1200/JCO.21.01436>, <https://doi.org/10.3310/HTNB6908>, <https://doi.org/10.1177/17407745211069879> ;
  onco:status "completed" ;
  onco:phase "platform" ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/histopathology-ihc/> ;
  onco:drugs <https://onco.cc/drugs/adavosertib/>, <https://onco.cc/drugs/capecitabine/> ;
  onco:companies <https://onco.cc/companies/mrc-ctu/> ;
  onco:institutions <https://onco.cc/institutions/uclh/>, <https://onco.cc/institutions/cruk/>, <https://onco.cc/institutions/oxford-cancer/> ;
  onco:terms <https://onco.cc/terms/master-protocol/>, <https://onco.cc/terms/seamless-adaptive/>, <https://onco.cc/terms/basket-umbrella-platform/>, <https://onco.cc/terms/interim-analysis/> ;
  onco:people <https://onco.cc/people/tim-maughan/>, <https://onco.cc/people/matt-seymour/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-trial-design/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-brown-clin-trials/>, <https://onco.cc/key-papers/paper-seligmann-j-clin-oncol/>, <https://onco.cc/key-papers/paper-adams-j-clin-oncol/> .