# OnCo record folfoxiri (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/folfoxiri/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "folfoxiri" ;
  schema:name "FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan)"@en ;
  schema:description "All three of the active bowel cancer chemotherapy drugs given together instead of two. It shrinks more tumours than a doublet and is chosen when shrinking the tumour is what matters, usually with bevacizumab."@en ;
  schema:url <https://onco.cc/drugs/folfoxiri/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1403108>, <https://doi.org/10.1016/S1470-2045(19)30862-9>, <https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1428> ;
  onco:status "established" ;
  onco:modality "Cytotoxic regimen" ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/platinum/>, <https://onco.cc/technologies/topoisomerase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/dpyd/>, <https://onco.cc/targets/ugt1a1/> ;
  onco:drugs <https://onco.cc/drugs/fluorouracil/>, <https://onco.cc/drugs/leucovorin/>, <https://onco.cc/drugs/oxaliplatin/>, <https://onco.cc/drugs/irinotecan/>, <https://onco.cc/drugs/bevacizumab/> ;
  onco:trials <https://onco.cc/trials/tribe/>, <https://onco.cc/trials/tribe2/>, <https://onco.cc/trials/cairo5/> .