# OnCo record g12d-plus-pan-ras (pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pairings/g12d-plus-pan-ras/>
  a schema:MedicalTherapy ;
  onco:kind "pairing" ;
  schema:identifier "g12d-plus-pan-ras" ;
  schema:name "G12D-selective + pan-RAS(ON) inhibitor (zoldonrasib + daraxonrasib)"@en ;
  schema:description "A drug that hits the exact mutation plus a drug that hits every RAS protein, so the tumour cannot escape through a wild-type RAS cousin."@en ;
  schema:url <https://onco.cc/pairings/g12d-plus-pan-ras/> ;
  schema:dateModified "2026-09-21"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT06040541>, <https://www.globenewswire.com/news-release/2026/07/02/3321282/0/en/revolution-medicines-presents-phase-1-2-clinical-data-for-zoldonrasib-combination-regimens-in-patients-with-ras-g12d-metastatic-pancreatic-cancer-at-esmo-gastrointestinal-cancers-c.html> ;
  onco:cancers <https://onco.cc/cancers/pancreatic/> ;
  onco:targets <https://onco.cc/targets/kras/> ;
  onco:drugs <https://onco.cc/drugs/zoldonrasib/>, <https://onco.cc/drugs/daraxonrasib/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> ;
  onco:trials <https://onco.cc/trials/nct06040541/> ;
  onco:pairs <https://onco.cc/drugs/zoldonrasib/>, <https://onco.cc/drugs/daraxonrasib/> .