# OnCo record gain-igbc (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/gain-igbc/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "gain-igbc", "NCT03673072" ;
  schema:name "GAIN (AIO/CALGP/ACO)"@en ;
  schema:alternateName "GAIN"@en, "GAIN-Trial"@en ;
  schema:description "The German GAIN trial tried to test chemotherapy before the second operation for gallbladder cancer found by chance. It planned 333 patients but closed in October 2024 after enrolling 68, so it is unlikely to answer the question on its own."@en ;
  schema:url <https://onco.cc/trials/gain-igbc/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT03673072>, <https://doi.org/10.1186/s12885-020-6610-4> ;
  onco:status "completed" ;
  onco:phase "3" ;
  onco:related <https://onco.cc/trials/opt-in/> ;
  onco:cancers <https://onco.cc/cancers/gallbladder/>, <https://onco.cc/cancers/cholangiocarcinoma/> ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/platinum/>, <https://onco.cc/technologies/gallbladder-cancer-surgery/> ;
  onco:drugs <https://onco.cc/drugs/gemcitabine-cisplatin/>, <https://onco.cc/drugs/gemcitabine/>, <https://onco.cc/drugs/cisplatin/> ;
  onco:institutions <https://onco.cc/institutions/krankenhaus-nordwest/> ;
  onco:terms <https://onco.cc/terms/radical-cholecystectomy/>, <https://onco.cc/terms/neoadjuvant-adjuvant/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-gain-trial-protocol-bmc-cancer-2020/>, <https://onco.cc/key-papers/paper-varshney-neoadjuvant-incidental-gallbladder-cancer-systematic-review-ahbps-2025/> .