# OnCo record gart (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/gart/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "gart" ;
  schema:name "GART (trifunctional purine synthesis enzyme)"@en ;
  schema:description "GART is one of the enzymes that builds purines from scratch; pemetrexed blocks it alongside thymidylate synthase, which is why the drug starves fast-growing lung and mesothelioma cells."@en ;
  schema:url <https://onco.cc/targets/gart/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Trifunctional_purine_biosynthetic_protein_adenosine-3>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4163>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000159131>, <https://www.uniprot.org/uniprotkb/P22102/entry>, <https://www.ncbi.nlm.nih.gov/gene/2618> ;
  schema:citation <https://www.uniprot.org/uniprotkb/P22102/entry>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4163>, <https://www.ebi.ac.uk/chembl/explore/target/CHEMBL3972> ;
  schema:alternateName "GART" ;
  onco:targetClass "enzyme" ;
  onco:firstDescribed "1990"^^xsd:gYear ;
  onco:related <https://onco.cc/targets/tyms/>, <https://onco.cc/targets/dhfr/> ;
  onco:cancers <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/mesothelioma/> ;
  onco:drugs <https://onco.cc/drugs/pemetrexed/> .