# OnCo record gata6-classical-basal-marker (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/gata6-classical-basal-marker/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "gata6-classical-basal-marker" ;
  schema:name "GATA6 as the marker of classical versus basal-like pancreatic cancer"@en ;
  schema:alternateName "GATA6"@en, "GATA6 in situ hybridisation"@en, "GATA6-high"@en, "GATA6-low"@en, "GATA6 expression in pancreatic cancer"@en ;
  schema:description "GATA6 is the transcription factor that separates the two pancreatic cancer subtypes that survive every re-analysis: classical tumours express it, basal-like (squamous) tumours have lost it. A GATA6 stain on a biopsy can therefore call the subtype that predicts how a tumour answers first-line chemotherapy, although no guideline yet acts on the result."@en ;
  schema:url <https://onco.cc/terms/gata6-classical-basal-marker/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1158/1078-0432.CCR-19-3724>, <https://doi.org/10.1158/1078-0432.CCR-17-2994>, <https://doi.org/10.1038/s41588-019-0566-9> ;
  onco:tag "pancreatic-molecular" ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/metastatic-pdac/>, <https://onco.cc/cancers/locally-advanced-pdac/> ;
  onco:technologies <https://onco.cc/technologies/rna-seq/> ;
  onco:targets <https://onco.cc/targets/kras/> ;
  onco:terms <https://onco.cc/terms/classical-vs-basal-like/>, <https://onco.cc/terms/basal-like/>, <https://onco.cc/terms/kras-allelic-imbalance/>, <https://onco.cc/terms/compass-study-pancreatic/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-okane-gata6-basal-like-compass-ccr-2020/>, <https://onco.cc/key-papers/paper-aung-compass-early-results-ccr-2018/>, <https://onco.cc/key-papers/paper-chan-seng-yue-pancreatic-transcription-phenotypes-nat-genet-2020/> .