# OnCo record gbm-agile (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/gbm-agile/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "gbm-agile", "NCT03970447" ;
  schema:name "GBM AGILE"@en ;
  schema:alternateName "GBM-AGILE"@en, "Glioblastoma Adaptive Global Innovative Learning Environment"@en ;
  schema:description "GBM AGILE is the glioblastoma trial that never ends: new drugs enter, are tested against the same standard treatment in newly diagnosed and recurrent patients at once, and either graduate to a confirmatory stage or are dropped. Its first drug, regorafenib, did not help, which the trial established faster and more cheaply than a stand-alone study would have."@en ;
  schema:url <https://onco.cc/trials/gbm-agile/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT03970447>, <https://www.gcaresearch.org>, <https://doi.org/10.1158/1078-0432.CCR-17-0764>, <https://doi.org/10.1200/JCO-25-01137>, <https://doi.org/10.1200/JCO-26-00444> ;
  onco:status "recruiting" ;
  onco:phase "platform" ;
  schema:startDate "2019-07-30" ;
  onco:cancers <https://onco.cc/cancers/glioblastoma/>, <https://onco.cc/cancers/brain-tumours/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/digital-twins-trials/> ;
  onco:drugs <https://onco.cc/drugs/regorafenib/>, <https://onco.cc/drugs/temozolomide/>, <https://onco.cc/drugs/lomustine/> ;
  onco:institutions <https://onco.cc/institutions/ucla-jonsson/> ;
  onco:terms <https://onco.cc/terms/master-protocol/>, <https://onco.cc/terms/seamless-adaptive/>, <https://onco.cc/terms/interim-analysis/> ;
  onco:people <https://onco.cc/people/timothy-cloughesy/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-trial-design/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-alexander-clin-cancer-res/>, <https://onco.cc/key-papers/paper-wen-j-clin-oncol/>, <https://onco.cc/key-papers/paper-ballman-j-clin-oncol/> .