# OnCo record gbrca-mutation (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/gbrca-mutation/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "gbrca-mutation" ;
  schema:name "Germline BRCA mutation (gBRCA)"@en ;
  schema:alternateName "gBRCA"@en, "gBRCAm"@en, "BRCA-mutated"@en, "BRCA-mutant"@en, "BRCA mutation"@en, "BRCA carriers"@en, "BRCA carrier"@en, "BRCA1/2"@en, "BRCA1"@en, "BRCA2"@en, "sBRCA"@en, "somatic BRCA"@en, "BRCA-deficient"@en, "BRCA wild-type"@en, "BRCA status"@en, "HRR mutation"@en, "HRR-mutant"@en, "HRRm"@en, "PALB2"@en, "BRCA mutations"@en ;
  schema:description "An inherited fault in the BRCA1 or BRCA2 gene, present in every cell from birth, that greatly raises the risk of breast, ovarian, prostate and pancreatic cancer and makes those cancers sensitive to PARP inhibitors and platinum."@en ;
  schema:url <https://onco.cc/terms/gbrca-mutation/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/BRCA_mutation> ;
  schema:citation <https://en.wikipedia.org/wiki/BRCA_mutation> ;
  onco:related <https://onco.cc/terms/hrd/>, <https://onco.cc/terms/germline-vs-somatic/>, <https://onco.cc/terms/hereditary-cancer-syndromes/>, <https://onco.cc/terms/salpingo-oophorectomy/> ;
  onco:cancers <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/prostate-mcrpc/> ;
  onco:sections <https://onco.cc/fronts/targeted-therapy/>, <https://onco.cc/fronts/prevention/> ;
  onco:technologies <https://onco.cc/technologies/parp-inhibitor/>, <https://onco.cc/technologies/germline-testing/> ;
  onco:targets <https://onco.cc/targets/brca/> ;
  onco:drugs <https://onco.cc/drugs/olaparib/> ;
  onco:trials <https://onco.cc/trials/olympia/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-pritchard-inherited-dna-repair-metastatic-prostate-nejm-2016/>, <https://onco.cc/key-papers/paper-castro-germline-brca-prostate-outcomes-jco-2013/> .