# OnCo record gene-amplification (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/gene-amplification/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "gene-amplification" ;
  schema:name "Gene amplification and copy-number change"@en ;
  schema:alternateName "amplification"@en, "amplified"@en, "amplifications"@en, "copy number"@en, "copy-number"@en, "copy number alteration"@en, "copy number gain"@en, "gene copy number"@en, "MYCN-amplified"@en, "MET amplification"@en, "CCNE1 amplification"@en, "deletion"@en, "homozygous deletion"@en, "del(17p)"@en, "1q gain"@en, "loss of heterozygosity"@en, "LOH"@en, "genomic instability"@en, "chromosomal instability"@en, "aneuploidy"@en ;
  schema:description "Cancer cells often have extra copies of a growth gene (amplification) or have lost copies of a protective one (deletion), rather than a spelling change within the gene. Extra copies of HER2 or MYCN are classic examples that change treatment."@en ;
  schema:url <https://onco.cc/terms/gene-amplification/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Gene_duplication> ;
  schema:citation <https://en.wikipedia.org/wiki/Gene_duplication> ;
  onco:related <https://onco.cc/terms/fish/>, <https://onco.cc/terms/her2-positive/>, <https://onco.cc/terms/hrd/>, <https://onco.cc/terms/cytogenetics/> ;
  onco:sections <https://onco.cc/fronts/diagnostics/> ;
  onco:technologies <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/histopathology-ihc/> ;
  onco:targets <https://onco.cc/targets/her2/>, <https://onco.cc/targets/mdm2/>, <https://onco.cc/targets/prmt5-mtap/> .