# OnCo record genome-instability-mutation (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/genome-instability-mutation/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "genome-instability-mutation" ;
  schema:name "Enabling characteristic: genome instability and mutation"@en ;
  schema:description "Cancers mutate faster than normal cells because their DNA repair and chromosome segregation are broken. This fuels every other hallmark."@en ;
  schema:url <https://onco.cc/terms/genome-instability-mutation/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/The_Hallmarks_of_Cancer> ;
  schema:citation <https://doi.org/10.1158/2159-8290.CD-21-1059> ;
  onco:tag "hallmark" ;
  onco:technologies <https://onco.cc/technologies/parp-inhibitor/>, <https://onco.cc/technologies/hrd-testing/> ;
  onco:targets <https://onco.cc/targets/brca/>, <https://onco.cc/targets/parp/>, <https://onco.cc/targets/atr/>, <https://onco.cc/targets/tp53/> ;
  onco:pathways <https://onco.cc/pathways/ddr/>, <https://onco.cc/pathways/replication-stress/>, <https://onco.cc/pathways/chromosomal-instability/> ;
  onco:terms <https://onco.cc/terms/msi/>, <https://onco.cc/terms/tmb/>, <https://onco.cc/terms/hrd/>, <https://onco.cc/terms/mutational-signature/>, <https://onco.cc/terms/whole-genome-doubling/> .