# OnCo record germinal-centre-reaction (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/germinal-centre-reaction/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "germinal-centre-reaction" ;
  schema:name "The germinal centre reaction"@en ;
  schema:alternateName "Germinal centre"@en, "Germinal center reaction"@en, "Somatic hypermutation and class switching"@en, "Affinity maturation"@en ;
  schema:description "To make a good antibody, a B cell has to deliberately damage its own DNA and keep dividing while it does. The germinal centre is where that happens, under strict time limits. Most B-cell lymphomas are cells that went through it and did not come out."@en ;
  schema:url <https://onco.cc/pathways/germinal-centre-reaction/> ;
  schema:dateModified "2026-09-30"^^xsd:date ;
  schema:citation <https://doi.org/10.1126/science.3929382>, <https://doi.org/10.1038/ng.518>, <https://doi.org/10.1038/nature09730>, <https://doi.org/10.1038/35000501> ;
  onco:tag "pathway", "lymphoma" ;
  onco:cancers <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/follicular-lymphoma/>, <https://onco.cc/cancers/burkitt-lymphoma/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/>, <https://onco.cc/cancers/primary-mediastinal-b-cell-lymphoma/> ;
  onco:targets <https://onco.cc/targets/bcl6/>, <https://onco.cc/targets/ezh2/>, <https://onco.cc/targets/crebbp/>, <https://onco.cc/targets/ep300/>, <https://onco.cc/targets/bcl2/>, <https://onco.cc/targets/myc-gene/>, <https://onco.cc/targets/kmt2d/> ;
  onco:pathways <https://onco.cc/pathways/epigenetic-reprogramming/>, <https://onco.cc/pathways/apoptosis-bcl2/>, <https://onco.cc/pathways/bcr-signalling/>, <https://onco.cc/pathways/myc/> ;
  onco:terms <https://onco.cc/terms/lymphoma-bio-germinal-centre/>, <https://onco.cc/terms/cell-of-origin/> .