# OnCo record germline-all-predisposition (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/germline-all-predisposition/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "germline-all-predisposition" ;
  schema:name "Inherited susceptibility to acute lymphoblastic leukaemia (PAX5, ETV6, IKZF1)"@en ;
  schema:alternateName "germline ALL predisposition"@en, "inherited ALL susceptibility"@en, "PAX5 germline"@en, "ETV6 germline"@en, "IKZF1 germline"@en, "familial acute lymphoblastic leukaemia"@en ;
  schema:description "A small share of children with acute lymphoblastic leukaemia were born with a gene change, in genes such as PAX5, ETV6 or IKZF1, that raised their risk. Finding it guides follow-up, testing of brothers and sisters, and the choice of a family stem cell donor."@en ;
  schema:url <https://onco.cc/terms/germline-all-predisposition/> ;
  schema:dateModified "2026-11-04"^^xsd:date ;
  schema:citation <https://doi.org/10.1158/1078-0432.ccr-24-0685>, <https://www.england.nhs.uk/wp-content/uploads/2018/08/rare-and-inherited-disease-national-genomics-test-directory-v9.xlsx> ;
  onco:tag "gap-fill", "hereditary" ;
  onco:related <https://onco.cc/terms/ataxia-telangiectasia/>, <https://onco.cc/terms/bloom-syndrome/>, <https://onco.cc/terms/constitutional-mismatch-repair-deficiency/> ;
  onco:cancers <https://onco.cc/cancers/all-leukemia/> ;
  onco:technologies <https://onco.cc/technologies/germline-testing/> ;
  onco:targets <https://onco.cc/targets/pax5/>, <https://onco.cc/targets/etv6/> ;
  onco:terms <https://onco.cc/terms/hereditary-cancer-syndromes/> .