# OnCo record germline-myeloid-predisposition (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/germline-myeloid-predisposition/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "germline-myeloid-predisposition" ;
  schema:name "Germline predisposition to myeloid neoplasms (inherited predisposition to AML and MDS)"@en ;
  schema:alternateName "inherited predisposition to acute myeloid leukaemia"@en, "hereditary myeloid malignancy"@en, "haematopoietic malignancy predisposition"@en, "myeloid neoplasms with germline predisposition"@en, "familial AML"@en ;
  schema:description "Some people are born with a gene change that raises their risk of myelodysplastic syndrome or acute myeloid leukaemia, through genes such as DDX41, RUNX1, GATA2 and CEBPA or bone marrow failure conditions. Testing matters because it changes surveillance, treatment and which relative can safely donate stem cells."@en ;
  schema:url <https://onco.cc/terms/germline-myeloid-predisposition/> ;
  schema:dateModified "2026-11-04"^^xsd:date ;
  schema:citation <https://doi.org/10.1158/1078-0432.ccr-24-0685>, <https://www.england.nhs.uk/wp-content/uploads/2018/08/rare-and-inherited-disease-national-genomics-test-directory-v9.xlsx> ;
  onco:tag "gap-fill", "hereditary" ;
  onco:related <https://onco.cc/terms/ddx41-myeloid-predisposition/>, <https://onco.cc/terms/familial-platelet-disorder-runx1/>, <https://onco.cc/terms/fanconi-anaemia/>, <https://onco.cc/terms/shwachman-diamond-syndrome/>, <https://onco.cc/terms/dyskeratosis-congenita/> ;
  onco:cancers <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/mds/> ;
  onco:technologies <https://onco.cc/technologies/allogeneic-hsct/>, <https://onco.cc/technologies/germline-testing/> ;
  onco:targets <https://onco.cc/targets/ddx41/>, <https://onco.cc/targets/runx1/>, <https://onco.cc/targets/gata2/>, <https://onco.cc/targets/cebpa/>, <https://onco.cc/targets/etv6/> ;
  onco:terms <https://onco.cc/terms/hereditary-cancer-syndromes/> .