# OnCo record gist-kit-exon-11 (cancer). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/cancers/gist-kit-exon-11/>
  a schema:MedicalCondition ;
  onco:kind "cancer" ;
  schema:identifier "gist-kit-exon-11" ;
  schema:name "KIT exon 11-mutant GIST"@en ;
  schema:alternateName "Imatinib-sensitive GIST"@en, "KIT-mutant gastrointestinal stromal tumour"@en, "Classic GIST"@en ;
  schema:description "Most GISTs are driven by a mutation in exon 11 of the KIT gene, which keeps the KIT growth receptor switched on. Imatinib blocks it: given for three years after surgery in higher-risk tumours it prevents relapse and extends life, and in metastatic disease it controls the tumour for years before resistance develops."@en ;
  schema:url <https://onco.cc/cancers/gist-kit-exon-11/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Gastrointestinal_stromal_tumor> ;
  schema:citation <https://pubmed.ncbi.nlm.nih.gov/22453568/>, <https://pubmed.ncbi.nlm.nih.gov/19303137/>, <https://en.wikipedia.org/wiki/Gastrointestinal_stromal_tumor> ;
  onco:tag "subtype-page" ;
  onco:pipeline <https://onco.cc/drugs/idrx-42/>, <https://onco.cc/drugs/nb003/>, <https://onco.cc/drugs/bezuclastinib/>, <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/trials/insight-gist/> ;
  onco:standardOfCare <https://onco.cc/drugs/imatinib/>, <https://onco.cc/technologies/robotic-surgery/>, <https://onco.cc/targets/kit/>, <https://onco.cc/drugs/imatinib/>, <https://onco.cc/targets/kit/>, <https://onco.cc/drugs/imatinib/>, <https://onco.cc/technologies/ct/>, <https://onco.cc/targets/kit/>, <https://onco.cc/drugs/imatinib/>, <https://onco.cc/drugs/sunitinib/>, <https://onco.cc/drugs/regorafenib/>, <https://onco.cc/drugs/ripretinib/>, <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/terms/ctdna/> .