# OnCo record gist-pdgfra-d842v (cancer). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/cancers/gist-pdgfra-d842v/>
  a schema:MedicalCondition ;
  onco:kind "cancer" ;
  schema:identifier "gist-pdgfra-d842v" ;
  schema:name "PDGFRA D842V-mutant GIST"@en ;
  schema:alternateName "PDGFRA exon 18-mutant GIST"@en, "Imatinib-resistant PDGFRA GIST"@en, "Epithelioid gastric GIST"@en ;
  schema:description "PDGFRA D842V GIST is driven by a mutation in the PDGFRA receptor rather than KIT, and it does not respond to imatinib at all. Avapritinib, designed to fit the mutant activation loop, shrinks nearly nine in ten of these tumours and is the standard treatment for advanced disease; localised tumours are cured by surgery alone."@en ;
  schema:url <https://onco.cc/cancers/gist-pdgfra-d842v/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Avapritinib> ;
  schema:citation <https://pubmed.ncbi.nlm.nih.gov/32615108/>, <https://en.wikipedia.org/wiki/Avapritinib> ;
  onco:tag "subtype-page" ;
  onco:pipeline <https://onco.cc/drugs/avapritinib/>, <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/drugs/idrx-42/> ;
  onco:standardOfCare <https://onco.cc/technologies/robotic-surgery/>, <https://onco.cc/targets/pdgfra/>, <https://onco.cc/drugs/avapritinib/>, <https://onco.cc/targets/pdgfra/>, <https://onco.cc/targets/kit/>, <https://onco.cc/drugs/regorafenib/>, <https://onco.cc/trials/voyager/>, <https://onco.cc/technologies/liquid-biopsy/> .