# OnCo record glucarpidase (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/glucarpidase/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "glucarpidase" ;
  schema:name "Glucarpidase"@en ;
  schema:alternateName "Carboxypeptidase G2"@en, "Voraxaze" ;
  schema:description "Glucarpidase (Voraxaze) is a single emergency injection that chops up methotrexate in the blood when a patient's kidneys have failed to clear a high dose, preventing potentially fatal toxicity."@en ;
  schema:url <https://onco.cc/drugs/glucarpidase/> ;
  schema:dateModified "2026-09-10"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Glucarpidase> ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=glucarpidase>, <https://www.cancer.gov/about-cancer/treatment/drugs/glucarpidase> ;
  onco:status "approved" ;
  onco:tag "nci-list", "supportive" ;
  onco:modality "Recombinant bacterial enzyme (rescue agent)" ;
  onco:approval "US 2012: Toxic plasma methotrexate concentrations with delayed clearance due to impaired renal function" ;
  onco:related <https://onco.cc/drugs/methotrexate/> ;
  onco:companies <https://onco.cc/companies/serb-pharmaceuticals/> ;
  onco:trials <https://onco.cc/trials/nct01305655/>, <https://onco.cc/trials/nct00634322/>, <https://onco.cc/trials/nct02022358/> .