# OnCo record h3-k27m (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/h3-k27m/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "h3-k27m" ;
  schema:name "H3 K27M mutation"@en ;
  schema:alternateName "H3 K27M"@en, "H3K27M"@en, "H3F3A K27M"@en, "H3-3A K27M"@en, "K27M"@en, "H3 K27-altered"@en, "H3 K27M-mutant diffuse midline glioma"@en ;
  schema:description "H3 K27M is a single change in a histone that defines diffuse midline glioma, including the brain-stem tumour DIPG. In 2025 dordaviprone became the first drug approved for tumours carrying it."@en ;
  schema:url <https://onco.cc/biomarkers/h3-k27m/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ad45b43e-fdef-47ad-9c34-055b41bdc576> ;
  onco:tag "biomarker", "glioma", "paediatric" ;
  onco:related <https://onco.cc/biomarkers/mgmt-promoter-methylation/>, <https://onco.cc/biomarkers/idh1-r132/> ;
  onco:cancers <https://onco.cc/cancers/dipg-dmg/>, <https://onco.cc/cancers/paediatric-high-grade-glioma/> ;
  onco:drugs <https://onco.cc/drugs/dordaviprone/> ;
  onco:terms <https://onco.cc/terms/h3k27m/> .