# OnCo record halo-301 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/halo-301/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "halo-301", "NCT02715804" ;
  schema:name "HALO 109-301"@en ;
  schema:alternateName "HALO-301"@en, "HALO 301"@en ;
  schema:description "HALO-301 was the phase 3 test of breaking down the dense stroma of pancreatic tumours with a hyaluronidase enzyme so chemotherapy could reach them; response rates went up but survival did not move, and the stroma-busting idea in this form was abandoned."@en ;
  schema:url <https://onco.cc/trials/halo-301/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT02715804>, <https://doi.org/10.1200/JCO.20.00590> ;
  onco:status "negative" ;
  onco:phase "3" ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/metastatic-pdac/> ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/> ;
  onco:drugs <https://onco.cc/drugs/pegvorhyaluronidase-alfa/>, <https://onco.cc/drugs/gemcitabine-nab-paclitaxel/> ;
  onco:companies <https://onco.cc/companies/halozyme/> ;
  onco:terms <https://onco.cc/terms/desmoplasia/>, <https://onco.cc/terms/pancreatic-failed-programmes/> ;
  onco:people <https://onco.cc/people/eric-van-cutsem/> .