# OnCo record hand-foot-syndrome-prevention-and-dose-modification (protocol). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/protocols/hand-foot-syndrome-prevention-and-dose-modification/>
  a schema:MedicalGuideline ;
  onco:kind "protocol" ;
  schema:identifier "hand-foot-syndrome-prevention-and-dose-modification" ;
  schema:name "Hand-foot syndrome and hand-foot skin reaction: prevention, skin care and dose changes"@en ;
  schema:alternateName "hand-foot syndrome"@en, "HFS"@en, "palmar-plantar erythrodysesthesia"@en, "PPE"@en, "PPES"@en, "hand-foot skin reaction"@en, "HFSR"@en, "capecitabine hand-foot syndrome"@en, "urea cream for hand-foot"@en, "topical diclofenac for hand-foot syndrome"@en ;
  schema:description "Capecitabine, liposomal doxorubicin and tablets such as sorafenib and regorafenib can make the palms and soles red, sore, peeling or blistered. From the start, avoid rubbing, heat and long soaks, wear well-fitting shoes and moisturise daily; with sorafenib, a 10 per cent urea cream from day one helps. If hands or feet become painful or limit what you do, stop capecitabine and call your team."@en ;
  schema:url <https://onco.cc/protocols/hand-foot-syndrome-prevention-and-dose-modification/> ;
  schema:dateModified "2026-11-11"^^xsd:date ;
  onco:tag "protocol", "hand-foot-syndrome", "skin-toxicity", "supportive-care" ;
  onco:related <https://onco.cc/drugs/celecoxib/> ;
  onco:sections <https://onco.cc/fronts/supportive-care/> ;
  onco:technologies <https://onco.cc/technologies/vitamin-b6-pyridoxine/> ;
  onco:drugs <https://onco.cc/drugs/capecitabine/>, <https://onco.cc/drugs/capox/>, <https://onco.cc/drugs/pegylated-liposomal-doxorubicin/>, <https://onco.cc/drugs/sorafenib/>, <https://onco.cc/drugs/regorafenib/>, <https://onco.cc/drugs/cabozantinib/>, <https://onco.cc/drugs/lenvatinib/>, <https://onco.cc/drugs/sunitinib/>, <https://onco.cc/drugs/tegafur-gimeracil-oteracil/> ;
  onco:terms <https://onco.cc/terms/hand-foot-syndrome/> .