# OnCo record harmoni-a (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/harmoni-a/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "harmoni-a", "NCT05184712" ;
  schema:name "HARMONi-A"@en ;
  schema:description "The first phase 3 win for ivonescimab, in lung cancer that has stopped responding to EGFR pills, and the basis of its first approval in China."@en ;
  schema:url <https://onco.cc/trials/harmoni-a/> ;
  schema:dateModified "2026-09-10"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT05184712>, <https://doi.org/10.1001/jama.2024.10613> ;
  onco:status "positive" ;
  onco:tag "china" ;
  onco:phase "3" ;
  schema:startDate "2022-01-25" ;
  onco:related <https://onco.cc/trials/harmoni-2/>, <https://onco.cc/trials/harmoni-3/> ;
  onco:cancers <https://onco.cc/cancers/nsclc/> ;
  onco:technologies <https://onco.cc/technologies/bispecific-antibody/> ;
  onco:targets <https://onco.cc/targets/pd1/>, <https://onco.cc/targets/vegf/>, <https://onco.cc/targets/egfr/> ;
  onco:drugs <https://onco.cc/drugs/ivonescimab/>, <https://onco.cc/drugs/pemetrexed/>, <https://onco.cc/drugs/carboplatin/> ;
  onco:companies <https://onco.cc/companies/akeso/>, <https://onco.cc/companies/summit-therapeutics/> ;
  onco:people <https://onco.cc/people/fang-wenfeng/>, <https://onco.cc/people/zhang-li-sysucc/>, <https://onco.cc/people/xia-michelle/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-harmoni-a-jama-2024/> .