# OnCo record hdac (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/hdac/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "hdac" ;
  schema:name "Histone deacetylases (HDAC)"@en ;
  schema:description "Histone deacetylases tighten the packaging of DNA so that genes are switched off. Drugs that block them loosen the packaging and can wake up genes that make lymphoma cells stop growing or die."@en ;
  schema:url <https://onco.cc/targets/hdac/> ;
  schema:dateModified "2026-09-10"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Histone_deacetylase> ;
  schema:citation <https://www.ncbi.nlm.nih.gov/gene/3065> ;
  onco:tag "epigenetic" ;
  schema:alternateName "HDAC1, HDAC2, HDAC3, HDAC6" ;
  onco:targetClass "enzyme" ;
  onco:cancers <https://onco.cc/cancers/peripheral-t-cell-lymphoma/>, <https://onco.cc/cancers/multiple-myeloma/> ;
  onco:drugs <https://onco.cc/drugs/romidepsin/>, <https://onco.cc/drugs/belinostat/>, <https://onco.cc/drugs/vorinostat/>, <https://onco.cc/drugs/abt-301/> .